Enthalpy-Entropy Compensation for Micellization of Alkyltrimethylammonium Bromides

A fundamental view of enthalpy–entropy compensation

Conductometric Study of the Thermodynamics of Micellization of Sodium dodecylsulfate (SDS) in the Presence of Some Aromatic Ammonium Salts

The effect of three organic aromatic salts - Phenyltrimethylammonium (PhTMAB), benzyltrimethylammonium (BzTMAB) and benzyltrimethylammonium (BzTEAB) bromides - on the micellization of sodium dodecylsulfate has been investigated by conductometric method. The critical micelle concentration (CMC) values were found to decrease with increase in the concentration of the aromatic ammonium salts. Therm...

Entropy-enthalpy compensation: fact or artifact?

The phenomenon of entropy-enthalpy (S-H) compensation is widely invoked as an explanatory principle in thermodynamic analyses of proteins, ligands, and nucleic acids. It has been suggested that this compensation is an intrinsic property of either complex, fluctuating, or aqueous systems. The questions examined here are whether the observed compensation is extra-thermodynamic (i.e., reflects any...

Entropy–enthalpy compensation as deduced from measurements of temperature dependence

The concept of entropy–enthalpy compensation has exercised a peculiar fascination for biochemists since it was first proposed.[1, 2] The idea is that if a particular rate constant or equation constant is measured for a series of sample of the same enzyme from different sources, the variations in enthalpies of activation or of reaction will largely cancelled out by variations in the correspondin...

Enthalpy-entropy compensation at play in human copper ion transfer

Copper (Cu) is an essential trace element but toxic in free form. After cell uptake, Cu is transferred, via direct protein-protein interactions, from the chaperone Atox1 to the Wilson disease protein (WD) for incorporation into Cu-dependent enzymes. Cu binds to a conserved C(1)XXC(2) motif in the chaperone as well as in each of the cytoplasmic metal-binding domains of WD. Here, we dissect mecha...